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Jiri Kassa Selected Research

Poisoning

9/2022Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870.
4/2022Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice.
10/2021Memantine and Its Combination with Acetylcholinesterase Inhibitors in Pharmacological Pretreatment of Soman Poisoning in Mice.
11/2020Influence of experimental end point on the therapeutic efficacy of the antinicotinic compounds MB408, MB442 and MB444 in treating nerve agent poisoned mice - a comparison with oxime-based treatment.
10/2020Interaction of Cucurbit[7]uril with Oxime K027, Atropine, and Paraoxon: Risky or Advantageous Delivery System?
12/2019The evaluation of oxidative damage of DNA after poisoning with nerve agents.
4/2018Evaluation of the Influence of Three Newly Developed Bispyridinium Anti-nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice.
1/2018Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings.
1/2018Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.
1/2018The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats.
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Jiri Kassa Research Topics

Disease

57Poisoning
09/2022 - 07/2005
4Alzheimer Disease (Alzheimer's Disease)
01/2018 - 10/2008
1Amnesia (Dissociative Amnesia)
01/2018
1Disease Progression
12/2015
1Neurodegenerative Diseases (Neurodegenerative Disease)
06/2014
1Long Term Adverse Effects
05/2009
1Organophosphate Poisoning
10/2008
1Neurobehavioral Manifestations
10/2008
1Heart Failure
09/2008

Drug/Important Bio-Agent (IBA)

48OximesIBA
09/2022 - 07/2005
28tabunIBA
09/2022 - 12/2006
20asoxime chloride (H16)IBA
01/2018 - 07/2005
15AtropineFDA LinkGeneric
10/2020 - 01/2007
14Nerve AgentsIBA
04/2022 - 12/2006
13SomanIBA
10/2021 - 09/2006
11Obidoxime Chloride (Obidoxime)IBA
01/2018 - 01/2007
10SarinIBA
11/2020 - 07/2005
10Trimedoxime (Trimedoxime Bromide)IBA
07/2017 - 09/2007
9cyclohexyl methylphosphonofluoridate (cyclosarin)IBA
11/2020 - 09/2006
7AcetylcholinesteraseIBA
03/2015 - 01/2007
4Cholinesterase Inhibitors (Anticholinesterases)IBA
10/2021 - 12/2015
3Tacrine (Cognex)FDA Link
01/2016 - 10/2008
3VX (EDIM)IBA
08/2013 - 09/2006
2Biological ProductsIBA
04/2022 - 11/2015
2MB442IBA
04/2018 - 01/2018
2MB444IBA
04/2018 - 01/2018
2MB408IBA
04/2018 - 01/2018
21- (4- carbamoylpyridinium)- 4- (3- fluoro- 4- hydroxyiminomethylpyridinium)- but- 2- eneIBA
11/2010 - 08/2010
2p38 Mitogen-Activated Protein KinasesIBA
05/2009 - 01/2007
2Transcription Factors (Transcription Factor)IBA
05/2009 - 01/2007
2Neuroprotective AgentsIBA
01/2009 - 01/2007
2Cholinergic Antagonists (Anticholinergics)IBA
10/2008 - 12/2006
2Pharmaceutical PreparationsIBA
10/2008 - 12/2006
1Memantine (Namenda)FDA Link
10/2021
1Paraoxon (E600)IBA
10/2020
1OrganophosphatesIBA
10/2020
1DNA (Deoxyribonucleic Acid)IBA
12/2019
1Quinuclidinyl BenzilateIBA
01/2018
16-chlorotacrineIBA
01/2018
1MB327IBA
06/2016
1PropaneIBA
06/2016
1Cholinesterases (Cholinesterase)IBA
01/2016
16- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA
11/2015
1Cholinergic ReceptorsIBA
06/2014
11- (4- carbamoylpyridinium)- 3- (4- hydroxyiminomethylpyridinium)- 2- oxapropaneIBA
03/2011
17- methoxy- 1,2,3,4- tetrahydroacridin- 9- amineIBA
10/2008
17-methoxytacrine (TA 03)IBA
10/2008
1Cholinesterase ReactivatorsIBA
10/2008
1Malathion (Karbofos)FDA LinkGeneric
01/2008
1Glutathione PeroxidaseIBA
01/2008
1Cholinergic Agents (Cholinergics)IBA
01/2008
1Glutathione (Reduced Glutathione)IBA
01/2008
1Glutathione Reductase (Glutathione-Disulfide Reductase)IBA
01/2008
1AntidotesIBA
09/2007
1Mitogen-Activated Protein KinasesIBA
01/2007
1Pyridostigmine Bromide (Pyridostigmine)FDA LinkGeneric
12/2006
1BenactyzineIBA
12/2006
1panpalIBA
12/2006
1S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolateIBA
09/2006

Therapy/Procedure

2Therapeutics
10/2020 - 01/2016